Chitosan and Hydroxypropyl Methylcellulose as release retardant for Aceclofenac

Plenty of natural polymers has been found effective to modulate the drug release. Numerous either alone or in combination with other were controlling In current study attempts made combine chitosan (degree deacetylation 88.42 %, Molecular weight 50,000 Da, and viscosity 93 CPS) HPMC K 15M retard release aceclofenac tablet formulation. The tablets prepared by wet granulation method evaluated for pre post- compression parameters. All pre-compression parameters within limit. mechanical strength was determined terms hardness friability values these range 4.16-5.22 kg/cm2 0.1-0.75% respectively. content 97.51 – 99.66 %. Weight variation test complied official limit as per Indian Pharmacopoeia. With increasing concentration both swelling index increased decrease. Highest up 8 h.